Formulation and Evaluation of Nail Drug Delivery System of Anti Fungal Drug

The purpose of this study was to prepare nail lacquer for drug delivery system anti fungal in order improve the physicochemical parameters that influence permeation through a plate reach systemic circulation and neighbouring target sites. success local topical therapy onychomycosis depends on achievement effective chemical concentrations into/through human plate; therefore, suitable antifungal must be coupled with an appropriate method. method should maximize effect active principle by aiding its diffusion into bed levels exceeding minimum inhibitory concentration (MIC) against infection dermatophytes. Thus, carrier may needed enhance penetration barrier.
 formulations were prepared simple mixing analyzed non volatile content, gloss, smoothness flow, studies, % content. Among all formulations, 2% oxiconazole, 6% nitrocellulose, 1% ethyl cellulose, 15% salicylic acid, 10% propylene glycol 2-H β-CD exhibited good release, content estimation zone inhibition i.e. F4 formulation. release profiles achieved 93.2% at 12 h. vitro ungual studies revealed vivo correlation. Nail substantially stable after 1 month storage 40±2℃.